I. Hypersensitivity
A. Introduction
1. Immediate type hypersensitivity
2. Delayed type hypersensitivity
B. Anaphylactic Rxns (type I)
1. Mechanism
2. Clinical forms
a) localized
b) systemic
symptoms
3. Prevention
a) avoid allergen
b) desensitization
C. Cytotoxic Rxns (type II)
1. Mechanism
2. Examples
a) transfusion reactions
b) Rh incompatibility
c) drug
sensitivities
D. Immune Complex Rxns (Type III)
1. Mechanism
2. Examples
a) streptococcal glomerulonephritis
b) rheumatoid
arthritis
E. Cell-Mediated hypersensitivity rxns (Type IV)
1. Mechanisms
2. Examples
a) Tb
b) contact
dermatitis
II. Transplantation Immunology
A. Types of grafts
1. Xenograft
2. Allograft
3. Isograft
4. Autograft
B. Mechanisms of rejection
1. T-cell direct killing
2. T-cell lymphokine production
3. Ab mediated
4. Immune complex
D. Graft vs. host (GVH) disease
1. histoincompatability
2. graft cells immunocompetent
3. host
cells immunodeficient
III. Tumor Immunology
A. Transformation of normal cells and response
B. Theory of immunologic surveillance
IV. Autoimmunity
A. Causes
B. Examples
1. Systemic Lupus Erythematosus (SLE)
multisystem involvement
2. Rheumatiod arthritis
abnormal IgG
3. Myasthenia gravis
autoantibody
to acetlycholine receptor
4. Insulin-dependent diabetes mellitus (IDDM)
autoantibodies
and T cells reactive to pancreas antigens and insulin
V. Immunodeficiency
A. Evidence of
1. Recurrent/chronic infections
2. High rate of malignancy
B. Classification
1. Causes
a) primary
b) acquired
2. Deficiency
a) B cells
b) T cells
c) both T
and B cells
d) complement
e) hypogammaglobulinemia
C. Examples
1. Bruton's Disease
2. DiGeorge's Syndrome