Syllabus

ANSC/PLSC 467/667: PARADIGMS IN CELL SIGNALING (3 Credits)
057 Townsend Hall
TR  11:00 AM – 12:15

INSTRUCTORS:                 Office                        Phone           E. mail    
Dr. Jung-Youn Lee           227 DBI                 x3230          JYLee@dbi.udel.edu
Dr. Mark S. Parcells        052 Townsend         x0114          Parcells@udel.edu

Course Materials: Handouts, Primary literature articles, Review articles

Grading: Based on (2) short papers (2-3 pages), Take-home mid-term and final examinations, paper presentation.  500 pt total

Lectures:   Dr. Lee, Dr. Parcells and Guest Lecturers

 

CLASS

DATE

TOPIC

MATERIALS

PRESENTER


1


2/6


Introduction & Methods I:
Molecular biological, Immunological, & inhibitors


Handouts


Parcells & Lee


2


2/8


Introduction & Methods II:
Cell biological, biochemical & genetics tools


Handouts


Parcells & Lee


3


2/13


Introduction & Methods II:
Microscopic methods and theory


Handouts


Guest


4


2/15


Direct Contact Signaling I:
Gap junctions, Receptors of Tissue Continuity


Papers


Parcells


5


2/20


Direct Contact Signaling II:
ECM signaling


Papers


Parcells (& Guest)


6


2/22


Direct Contact Signaling III:
Plant-microbe Interactions


Papers


Guest


7


2/27


Direct Contact Signaling IV:
Self Incompatibility


Papers


Lee


8


3/1


Signaling at a Distance I:
Short Distance Signaling in Plants


Papers


Lee


9


3/6


Signaling at a Distance II:
Short Distance Signaling in Animals- gradients & paracrine signaling, chemokines, GPCR


Papers


Parcells
(& Guest)


10


3/8


Signaling at a Distance III:
Long Distance Signaling in Plants


Papers


Lee


11


3/13


Signaling at a Distance IV:
Ligands/receptors: IL-1b, TNFRs, Toll-like Receptors


Papers


Parcells


12


3/15


Signaling at a Distance V:
Auxin Transport


Papers


Lee


13


3/20


Signal Relay from Surface to Nucleus:
Steroid Hormone, Cytokinin, Ethylene


Papers


Lee


14


3/22


Catch-up Lecture:
Distribution of Take-home Mid-term



Lee &
Parcells


15


4/3


Downstream Events:
STATs and SOCs in Immune signaling


Papers


Parcells


16


4/5


Cell Death:
Apoptotic Pathways


Papers


Parcells

 

17

 

4/10

 

Integration of Signals I:
Developmental Cell Patterning in Plants

 

Papers

 

Guest

 

18

 

4/12

 

Integration of Signals II:
Peptides & RNAs as signaling molecules

 

Papers

 

Lee


19


4/17


Integration of Signals III:
Second Messengers in plants


Papers


Lee


20


4/19


Integration of Signals IV:
Growth, Movement, Division


Papers


Parcells


21


4/24


Downstream Effects I:
Cis-elements and Trans-factors

Pap
rs


Parcells


22


4/26


Downstream Effects II:
Regulation of Chromatin Remodeling


Papers


Guest


23


5/1


Student presentation 1


Papers



24


5/3


Student presentation 3


Papers

 


25


5/8


Student presentation 3


Papers

 


26


5/15

 
Wrap-up, distribution of take-home final